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9,10-Anthracenediyl-bis(methylene)dimalonic acid

Cat. No. M31290
9,10-Anthracenediyl-bis(methylene)dimalonic acid Structure
Synonym:

ABDA; ABMDMA

Size Price Availability Quantity
25mg USD 145  USD145 In stock
50mg USD 190  USD190 In stock
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Biological Activity

9,10-Anthracenediyl-bis(methylene)dimalonic acid (ABDA) is a biological dye and indicator used to detect singlet oxygen generation (SOG). 9,10-Anthracenediyl-bis(methylene)dimalonic acid can be photobleached by singlet oxygen to its corresponding endoperoxide. This reaction can be monitored spectrophotometrically by recording the decrease of absorbance at 400 nm.

Chemical Information
Molecular Weight 410.37
Formula C22H18O8
CAS Number 307554-62-7
Form Solid
Solubility (25°C) DMSO 30 mg/mL
Water
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kazunori Yagi, et al. Org Biomol Chem. Development of water-soluble phenazine-2,3-diol-based photosensitizers for singlet oxygen generation

[2] Valdecir F Ximenes, et al. Photochem Photobiol. Taurine Chloramine and Hydrogen Peroxide as a Potential Source of Singlet Oxygen for Topical Application

[3] Andreea Campu, et al. Colloids Surf B Biointerfaces. ICG-loaded gold nano-bipyramids with NIR activatable dual PTT-PDT therapeutic potential in melanoma cells

[4] Tiago Entradas, et al. J Photochem Photobiol B. The detection sensitivity of commonly used singlet oxygen probes in aqueous environments

[5] M Gabriela Alvarez, et al. Bioorg Med Chem. Photodynamic inactivation of Candida albicans using bridged polysilsesquioxane films doped with porphyrin

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Keywords: 9,10-Anthracenediyl-bis(methylene)dimalonic acid, ABDA; ABMDMA supplier, Fluorescent Dye, inhibitors, activators

 
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