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8-Geranyloxypsoralen

Cat. No. M16271
8-Geranyloxypsoralen Structure
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Biological Activity

8-Geranyloxypsoralen

Chemical Information
CAS Number 7437-55-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hui-Juan Wu, et al. Oncol Rep. [Retracted] Bergamottin isolated from Citrus bergamia exerts in vitro and in vivo antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and i䲧璵Ỵ璶

[2] Guijie Li, et al. Drug Des Devel Ther. Characterization of Oxygenated Heterocyclic Compounds and in vitro Antioxidant Activity of Pomelo Essential Oil

[3] Imad Mennai, et al. Parasitol Int. Bio-guided isolation of leishmanicidal and trypanocidal constituents from Pituranthos battandieri aerial parts

[4] E C Row, et al. Bioorg Med Chem. Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4

[5] Shufeng Zhou, et al. Clin Pharmacokinet. Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs

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