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8-Epideoxyloganic acid

Cat. No. M16847
8-Epideoxyloganic acid Structure
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Biological Activity

8-Epideoxyloganic acid

Chemical Information
CAS Number 88668-99-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chryssoula Gousiadou, et al. Phytochemistry. Iridoid glucosides in the genus Sutera (Scrophulariaceae) as chemotaxonomic markers in tribe Limoselleae

[2] Yanjun Hao, et al. Zhongguo Zhong Yao Za Zhi. [Constituents and bioactivities of Lamiophlomis rotata]

[3] Yinggang Luo, et al. Lipids. Novel ceramides and a new glucoceramide from the roots of Incarvillea arguta

[4] M Nakamura, et al. Phytochemistry. Antinociceptive substances from Incarvillea delavayi

[5] R E Krull, et al. Phytochemistry. Iridoid glycoside biosynthesis in Penstemon secundiflorus. Another H-5, H-9 trans-iridoid glycoside

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