7OQL is a selective METTL3 inhibitor (IC50=0.054 µM).
| Molecular Weight | 590.8 |
| Formula | C37H46N6O |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related METTL3 Products |
|---|
| METTL3-IN-4
METTL3-IN-4 is a METTL3 inhibitor. |
| STM2120
STM2120 is a METTL3-METTL14 inhibitor with an IC50 of 64.5 μM. |
| STC-15
STC-15 is a METTL3 inhibitor used in the study of proliferative diseases such as cancer and autoimmune diseases. |
| UZH2
UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM. |
| UZH1
UZH1 is a racemate of UZH1a and UZH1b. |
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