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7ACC2

Cat. No. M6183
7ACC2 Structure
Size Price Availability Quantity
5mg USD 320 In stock
10mg USD 550 In stock
50mg USD 1880 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

lactate transport inhibitor 7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 309.32
Formula C18H15NO4
CAS Number 1472624-85-3
Purity >99%
Solubility 46 mg/mL in DMSO
Storage at -20°C
References

Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells.
Draoui N, et al. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17. PMID: 24095010.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 7ACC2 supplier, inhibitors

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