Free shipping on all orders over $ 500

7ACC2

Cat. No. M6183
7ACC2 Structure
Size Price Availability Quantity
5mg USD 240 In stock
10mg USD 440 In stock
50mg USD 1450 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

lactate transport inhibitor 7ACC2 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 309.32
Formula C18H15NO4
CAS Number 1472624-85-3
Purity >98%
Solubility 46 mg/mL in DMSO
Storage at -20°C
References

Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells.
Draoui N, et al. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17. PMID: 24095010.

Related Products
Photochlor

Photochlor is a lipophilic, second-generation, chlorin-based photosensitizer.

AMPPD

AMPPD is a new biochemistry ultrasensitive alkaline phosphatase substrate.

DM1-SMCC

DM1-SMCC is DM1 with a reactive linker SMCC, which can react with antibody to make ADC.

Mitapivat

Mitapivat is a potent human R-type pyruvate kinase (PKR) inhibitor.

VH-298

VH-298 is a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, with a Kd value of 80 to 90 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 7ACC2 supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.