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4-Octyl Itaconate

Cat. No. M9225
4-Octyl Itaconate Structure
Size Price Availability Quantity
100mg USD 100 In stock
200mg USD 175 In stock
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Quality Control
Biological Activity

4-Octyl Itaconate is a cell-permeable Itaconate derivative. 4-Octyl Itaconate is protective against lipopolysaccharide-induced lethality in vivo and decreases cytokine production.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 242.31
Formula C13H22O4
CAS Number 3133-16-2
Purity >99.5%
Solubility DMSO: ≥ 25 mg/mL
Storage at -20°C
References

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, et al. Nature. 2018 Apr 5;556(7699):113-117. PMID: 29590092.

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  Catalog
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Keywords: 4-Octyl Itaconate supplier, Nrf2, inhibitors

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