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4-Aminopyridine

Cat. No. M5368
4-Aminopyridine Structure
Size Price Availability Quantity
100mg USD 76 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

4-Aminopyridine(4AP) is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane. 4AP strongly potentiates transmitter release from the unmyelinated terminals of rat motor nerves, and the possibility arose that demyelinated axon membrane, which can conduct impulses continuously like an unmyelinated fibre, might further resemble its unmyelinated terminals by responding to 4AP. In testing this hypothesis. 4-AP blocked channels from the cytosolic face. 4-AP can both enhance and block Kv1.5 current and suggest that 4-AP can bind with different affinities to more than one site on Kv1.5 channels.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 94.11
Formula C5H6N2
CAS Number 504-24-5
Purity >98%
Solubility 10mM in DMSO
Storage at -20°C
References

Extracellular calcium modulates the inhibitory effect of 4-aminopyridine on Kv current in vascular smooth muscle cells.
Baeyens N, et al. Eur J Pharmacol. 2014 Jan 15;723:116-23. PMID: 24333216.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: 4-Aminopyridine supplier, Potassium Channel, inhibitors

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