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3-Methyl-L-histidine

Cat. No. M11357
3-Methyl-L-histidine  Structure
Size Price Availability Quantity
100mg USD 290  USD290 In stock
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Quality Control & Documentation
Biological Activity

3-methyl-L-Histidine can be used as a biomarker for meat consumption, especially chicken consumption, and soy product consumption.

Chemical Information
Molecular Weight 169.18
Formula C7H11N3O2
CAS Number 368-16-1
Solubility (25°C) Water ≥ 40 mg/mL
Storage RT, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jun Kaneko, et al. Sci Rep. Anserine (beta-alanyl-3-methyl-L-histidine) improves neurovascular-unit dysfunction and spatial memory in aged AβPPswe/PSEN1dE9 Alzheimer's-model mice

[2] Francesco Bellia, et al. Molecules. Carnosinases, their substrates and diseases

[3] W J White, et al. Meat Sci. Variations in the levels of 3-methyl-l-histidine of the myosins within the bovine carcass

[4] M Ducci, et al. Pol J Vet Sci. Concentrations of carnosine, anserine, L-histidine and 3-methyl histidine in boar spermatozoa and sheep milk by a modified HPLC method

[5] J C Robert, et al. Clin Chim Acta. Determination of 3 methyl-L-histidine in human urine by ion exchange high performance liquid chromatography. Applications to patients in post-operative surgical care

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