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2-Phenylglycine

Cat. No. M39103
2-Phenylglycine Structure
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Biological Activity

2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the W2 to W4 lactation period.

Chemical Information
Molecular Weight 151.16
Formula C8H9NO2
CAS Number 2835-06-5
Form Solid
Solubility (25°C) Water 3 mg/mL (ultrasonic and adjust pH to 12 with NaOH)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Siwen Wang et al. Molecules. High-Throughput UV Photoionization and Fragmentation of Neutral Biomolecules as a Structural Fingerprint

[2] Hong Zhang et al. Chem Biodivers. Design, Synthesis and Bioassay of 2-Phenylglycine Derivatives as Potential Pesticide Candidates

[3] Haruki Inada et al. J Org Chem. Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

[4] Shinji Takenaka et al. Biotechnol Lett. Enantioselective N-acetylation of 2-phenylglycine by an unusual N-acetyltransferase from Chryseobacterium sp

[5] José Alixandre de Sousa Luis et al. Molecules. Synthesis of new imidazolidin-2,4-dione and 2-thioxoimidazolidin-4-ones via C-phenylglycine derivatives

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