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2,6-Dimethoxy-1,4-benzoquinone

Cat. No. M17425
2,6-Dimethoxy-1,4-benzoquinone Structure
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2,6-Dimethoxy-1,4-benzoquinone

Chemical Information
CAS Number 530-55-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ahyoung Yoo, et al. Phytomedicine. 2,6-Dimethoxy-1,4-benzoquinone increases skeletal muscle mass and performance by regulating AKT/mTOR signaling and mitochondrial function

[2] Sakae Arimoto-Kobayashi, et al. Food Chem Toxicol. Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung䲧盷Ỵ相㧀盶羹甗

[3] Zi-Yi Zheng, et al. Food Chem. The joint effect of ultrasound and magnetic Fe 3 O 4 nanoparticles on the yield of 2,6-dimethoxy-ρ-benzoquinone from fermented wheat germ: Comparison of evolutionary algorithms and interactive analysis of paired-factors

[4] Tomonori Kamiya, et al. Food Chem Toxicol. 2,6-Dimethoxy-1,4-benzoquinone, isolation and identification of anti-carcinogenic, anti-mutagenic and anti-inflammatory component from the juice of Vitis coignetiae

[5] Hyo Jeong Son, et al. Planta Med. 2,6-Dimethoxy-1,4-benzoquinone Inhibits 3T3-L1 Adipocyte Differentiation via Regulation of AMPK and mTORC1

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Keywords: 2,6-Dimethoxy-1,4-benzoquinone supplier, Quinones, inhibitors, activators

 
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