1-Methyladenosine is an RNA modification originating essentially from two different reaction types, one catalyzed by enzymes and the other the result of the reaction of RNA with certain alkylating agents.
Molecular Weight | 281.27 |
Formula | C11H15N5O4 |
CAS Number | 15763-06-1 |
Solubility (25°C) | DMSO 100 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Weiyuan Yang, et al. The N 1-Methyladenosine Methylome of Petunia mRNA
[3] Xushen Xiong, et al. N 1-methyladenosine methylome in messenger RNA and non-coding RNA
[4] Chi Zhang, et al. Reversible RNA Modification N 1-methyladenosine (m 1 A) in mRNA and tRNA
[5] Boxuan Simen Zhao, et al. Post-transcriptional gene regulation by mRNA modifications
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