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1,9-Dideoxyforskolin

Cat. No. M6316
1,9-Dideoxyforskolin Structure
Size Price Availability
1mg USD 260  USD260 Custom Synthesis
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Quality Control & Documentation
Biological Activity

1,9-Dideoxyforskolin is a inactive analog of forskolin; does not activate adenylyl cyclase.

Chemical Information
Molecular Weight 378.5
Formula C22H34O5
CAS Number 64657-18-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hisahiro Hagiwara, et al. Synthetic transformation of ptychantin into forskolin and 1,9-dideoxyforskolin

[2] Y P Vedernikov, et al. Adenylate cyclase and potassium channels are involved in forskolin- and 1,9-dideoxyforskolin-induced inhibition of pregnant rat uterus contractility

[3] D R Shalinsky, et al. Selective modulation of vinblastine sensitivity by 1,9-dideoxyforskolin and related diterpenes in multidrug resistant tumour cells

[4] G White, et al. 1,9-Dideoxyforskolin does not mimic all cAMP and protein kinase A independent effects of forskolin on GABA activated ion currents in adult rat sensory neurons

[5] A Abe, et al. Calcium channel blocker-like action of 1,9-dideoxyforskolin in vascular smooth muscle

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