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STING Stimulator of Interferon Genes

Inhibitors

Cat.No.  Name Information
M21115 E7766 diammonium salt E7766 diammonium salt is a macrocyclic bridging STING agonist with a Kd of 40 nM. It has potent pan-genotypic and antitumor activity.
M21074 Ulevostinag Ulevostinag (MK-1454 ) is an intratumoral stimulator (STING) agonist of the interferon (IFN) gene that is being developed for the study of advanced solid tumors and lymphomas.
M20842 C-171 C-171 is a covalent small-molecule inhibitor of STING. C-171 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING.
M14125 STING-IN-2 STING-IN-2 (C-170) is a potent and covalent STING inhibitor. STING-IN-2 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). STING-IN-2 can be used for autoinflammatory disease research.
M14124 STING agonist-3 STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively.
M14122 Cyclic-di-GMP diammonium Cyclic di-GMP (c-di-GMP) diammonium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species.
M14121 Cyclic-di-GMP Cyclic-di-GMP (c-di-GMP) is a STING activator and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species.
M14120 cGAMP disodium cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA.
M14119 cGAMP diammonium cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA.
M11332 diABZI STING agonist-1 trihydrochloride DiABZI STING Agonist-1 (Trihydrochloride) is a selective agonist of interferon gene-stimulated receptor (STING), with EC50 scores of 130 nM and 186 nM in mice and humans, respectively.
M10766 ADU-S100 disodium salt ADU-S100 disodium salt (MIW815 disodium salt) is an activator (STING) of interferon gene stimulators with potent antitumor and immune activity.
M10765 ADU-S100 ammonium salt ADU-S100 ammonium salt (MIW815 ammonium salt) is an activator (STING) of interferon gene stimulators with potent antitumor and immune activity.
M10459 MSA-2 MSA-2 is an orally available non-nucleotide STING agonist with antitumor activity. MSA-2 shows EC50 values of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively.
M10299 c-di-AMP c-di-AMP (Cyclic diadenylate) is a STING agonist, it binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway.
M10126 H-151 H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation.
M10125 C-178 C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation.
M9923 SR-717 SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively.
M9893 C-176 C-176 is a potent small-molecule inhibitor of STING.
M9729 diABZI STING agonist 1 (compound 3) diABZI STING agonist-1 (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
M9084 STING-Inducer-1 STING-Inducer-1 (ML RR-S2 CDA) is an inducer of STING (stimulator of interferon genes).



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