Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M18434 | Ginkgolic acid 17:1 | Ginkgolic acid 17:1, a natural product isolated from Ginkgo biloba, inhibits constitutive and inducible STAT3 activation by inducing PTEN and SHP-1 tyrosine phosphatases. In addition, Ginkgolic acid C17:1 has anticancer activity. |
| M10065 | bpV(HOpic) potassium salt | BpV(HOpic) is a protein tyrosine phosphatases (PTPs) and a potent PTEN inhibitor with IC50 of 14 nM. |
| M8849 | VO-OHpic trihydrate | VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor. |
| M7290 | SF 1670 | SF 1670 is a pTPN2 and PTEN inhibitor. |
| M54687 | SQLE-IN-1 | SQLE-IN-1 is a squalene cyclooxygenase (SQLE) inhibitor and inhibits the proliferation and migration of Huh7 cells. In addition, SQLE-IN-1 inhibits cellular cholesterol production, increases PTEN expression, and inhibits PI3K and AKT expression. |
| M30078 | bpV(phen) | bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity. |
| M11330 | bpV(phen) trihydrate | BpV (PHEN) Trihydrate, an insulin mimic, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50 of 38 nM, 343 nM, and 920 nM for PTEN, PTP-β, and PTP-1B. BpV (PHEN) TriHydrate inhibits proliferation of protozoan parasites leishmania in vitro. |
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