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Proteasome Proteasome

Cat.No.  Name Information
M1902 MG132 MG132 is a specific and potent cell-permeable proteasome inhibitor (IC50 = 100 nM, Ki = 4 nM).
M2071 ONX-0914 Onx-0914 (PR-957) is a selective inhibitor of low molecular weight polypeptide 7 (LMP7), a chymotrypsin subunit of the immune proteasome. Onx-0914 blocks cytokine production and reduces the progression of experimental arthritis. Onx-0914 is a non-competitive irreversible inhibitor of mycobacterium proteasome (Ki=5.2 μM). Onx-0914 activates latent HIV-1 through HF-1-mediated p-TEFb activation.
M1686 Bortezomib (PS-341) Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM.
M2193 Epoxomicin Epoxomicin is a cell-permeable, novel proteasome inhibitor with an IC50 value of 4 nM.
M2035 IU1 IU1 is a reversible, small molecule inhibitor of deubiquitination by USP14 that demonstrates an IC50 value of 4-5 μM.
M3884 Celastrol (Tripterin) Celastrol (Tripterin) is a potent antioxidant and anti-inflammatory agent, as well as a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 μM.
M2995 Salinosporamide A Salinosporamide A (NPI-0052, Marizomib) is a novel marine derived proteasome inhibitor which inhibits CT-L, C-L, and T-L proteasome activities in human erythrocyte-derived 20S proteasomes with EC50 of 3.5 nM, 430 nM, 28 nM.
M2801 Lactacystin Lactacystin is a potent and selective inhibitor of the 20S proteasome.
M2285 MLN2238 MLN2238 inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively.
M2152 Carfilzomib Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of <5 nM. Carfilzomib irreverently selectively binds to the active site containing n-terminal threonine of the 20S proteasome and proteolytic core particles of the 26S proteasome.*The compound is unstable in solutions, freshly prepared is recommended.
M2150 Oprozomib Oprozomib (ONX 0912) is a novel orally proteasome inhibitor with potential antineoplastic activity.
M2122 MLN9708 MLN9708 is a novel orally bioactive proteasome inhibitor, inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 value of 3.4 nM.
M1844 ITMN-191 ITMN-191 (Danoprevir, RG7227) is a potent and orally active inhibitor of hepatitis C virus (HCV) NS3/4A serine protease with an IC50 of 1.6 nM.
M1724 CTP-518 CTP-518 is a novel HIV protease inhibitor. CTP-518 has the potential to be the first HIV protease inhibitor toeliminate the need to co-dose with a boosting agent.
M54581 NIC-0102 NIC-0102 is an orally potent proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammasome activation.NIC-0102 showed potent anti-inflammatory effects in vivo in a DSS-induced ulcerative colitis model. In addition, NIC-0102 inhibited the production of pro-IL-1β.
M54168 Ac-WLA-AMC Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate.
M53943 Ac-Nle-Pro-Nle-Asp-AMC Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome.
M52545 PR-39 PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor.
M52544 PSI PSI (Proteasome Inhibitor 1) is a potent proteasome inhibitor.
M52543 Suc-Ala-Ala-Pro-Phe-SBzl Suc-Ala-Ala-Pro-Phe-SBzl can be used as the substrate of rat intestinal mast cell protease (RMCP I), rat skeletal muscle mast cell protease (RMCP II) and Chymotrypsin.
M52542 Ac-Leu-Leu-Norleucinol Ac-Leu-Leu-Norleucinol (ALLN) is a calpain inhibitor, can be used for research of Acetaminophen induced acute liver damage, and lowers glutamic-oxalacetic transaminease (ALT) and glutamic-pyruvic transaminase (AST).
M52541 MeOSuc-Gly-Leu-Phe-AMC MeOSuc-Gly-Leu-Phe-AMC is a peptide substrate of proteasomal.
M52540 Z-Gly-Pro-Phe-Leu-CHO Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that acts as a highly selective and potent proteasomal inhibitor.
M52539 Suc-Gly-Gly-Phe-pNA Suc-Gly-Gly-Phe-pNA is the chymotrypsin substrate with an Km value of 1.6 mM.
M52538 Z-Leu-Leu-Tyr-COCHO Z-Leu-Leu-Tyr-COCHO is a potent chymotrypsin-like activity inhibitor with a Ki value of 3.0 nM.
M52537 Z-Ala-Arg-Arg-AMC Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome.




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