| Cat.No. | Name | Information |
|---|---|---|
| M41880 | FR 113680 | FR 113680 is a tripeptide substance P antagonist that interacts selectively with the NK1 neurokinin receptor. |
| M41879 | NK3R-IN-1 | NK3R-IN-1, a imidazolepiperazine derivative, is an orally active Neurokinin Receptor NK3R inhibitor. |
| M31368 | Osanetant | Osanetant (SR142801) is a potent, selective NK3 receptor antagonist for studies related to schizophrenia. |
| M31367 | SJX-653 | SJX-653 is an orally active, selective NK3R antagonist that inhibits vasodilation and may be used in studies related to hot flashes. |
| M31036 | Hemokinin 1, human TFA | Hemokinin 1, human TFA is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human TFA is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human TFA can produces an opioid-independent analgesia. |
| M31035 | [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA | [Lys5,MeLeu9,Nle10]-NKA(4-10) TFA is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM. |
| M30712 | Rolapitant hydrochloride | Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant hydrochloride does not interact with CYP3A4. Rolapitant hydrochloride shows potent anti-emetic activity in a ferret emesis model. |
| M30501 | Eledoisin | Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors. |
| M30317 | Orvepitant maleate | Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pKi of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment. |
| M30171 | Hemokinin 1, human | Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia. |
| M28611 | Benzomalvin A | Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with Ki values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively. |
| M28284 | [Lys5,MeLeu9,Nle10]-NKA(4-10) | [Lys5,MeLeu9,Nle10]-NKA(4-10) is a highly selective and potent NK2 receptor agonist, with an IC50 of 6.1 nM. |
| M28243 | RP 67580 | RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a Ki value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation. |
| M22349 | Fosaprepitant | Fosaprepitant is a precursor compound to Aprepitant and a neurokinin-1 receptor (NK1) antagonist that can be used in studies related to nausea and vomiting. |
| M14023 | NKP608 | NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo. |
| M14022 | Neurokinin A TFA | Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues. |
| M9200 | Ibodutant | Ibodutant (MEN15596) is a potent and selective tachykinin NK2 receptor antagonist with a pKi of 10.1. |
| M9185 | Serlopitant | Serlopitant is a selective Neurokinin-1 (NK-1) receptor antagonist. |
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