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NAMPT Nicotinamide phosphoribosyl transferase

Cat.No.  Name Information
M14476 GNE-617 hydrochloride GNE-617 hydrochloride is a specific NAMPT inhibitor that inhibits the biochemical activity of NAMPT with an IC50 of 5 nM and exhibits efficacy in xenograft models of cancer.
M11013 SBI-797812 SBI-797812 is an activator of NAMPT that is structurally similar to active site-directed NAMPT inhibitors, preventing these inhibitors from binding to NAMPT. SBI-797812 transforms NAMPT into a "super catalyst" that generates NMN more efficiently.
M9762 GNE-617 GNE-617 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM.
M9130 LSN3154567 LSN3154567 (also known as Nampt-IN-1) is a potent and elective NAMPT inhibitor, inhibits purified NAMPT with an IC50 of 3.1 nM.
M8901 CHS-828 CHS-828 (GMX1778) is a potent and specific inhibitor of NAMPT with IC50 and Kd value of <25 nM and 120 nM, respectively.
M3144 P7C3 P7C3 exerts its proneurogenic activity by protecting newborn neurons from apoptosis. Also enhances learning and memory in aged rats. Orally available and brain penetrant.
M3033 STF-118804 STF-118804 is a highly specific NAMPT inhibitor.
M42530 NAMPT degrader-3 NAMPT degrader-3 is a NAMPT degrader, depending on VHL- and proteasome manner.
M42529 Nampt activator-3 NAMPT activator-3, a NAT derivative, is a NAMPT activator with an EC50 of 2.6 μM and a KD of 132 nM.
M29654 Nampt-IN-8  Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS.
M28254 GNE-618  GNE-618 is a potent, orally active nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with an IC50 of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity.
M27930 GPP78 GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects.
M20823 OT-82 OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03   nM in non-HP cancer cells and 2.89   nM in HP cancer cells, respectively.




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