| Cat.No. | Name | Information |
|---|---|---|
| M6189 | Ossirene | Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta (IL-1β) converting enzyme. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene also inhibits Caspase-1. |
| M6223 | Tocilizumab | Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor. Tocilizumab prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab can be used for the research of rheumatoid arthritis and COVID-19. |
| M10139 | Anakinra | Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. |
| M1622 | Secukinumab | Secukinumab (AIN457) is a high-affinity monoclonal antibody against interleukin (IL-17A). Secukinumab (AIN457) is the first-in-class anti-IL-17 agent to be used in studies of plaque psoriasis, ankylosing spondylitis, and psoriatic arthritis. |
| M52850 | YVAD-CHO | YVAD-CHO is an interleukin-1β converting enzyme (ICE, caspase 1) inhibitor that can partially delay motoneurone death in lesioned facial nerve mice. |
| M52849 | Lib2-1 | Lib2-1, a macrocyclic peptide, is an IL-17C/IL-17RE interaction inhibitor. |
| M52817 | [D-Arg1, D-Phe5, D-Trp7, 9, Leu11]-Substance P | [D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P, a Substance P derivative, is a biased agonist toward neuropeptide and chemokine receptors. |
| M49645 | Balsalazide sodium hydrate | Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. |
| M49455 | CALY-002 | CALY-002 is a potential best-in-class (BIC), humanized monoclonal antibody targeting IL-15 for studies related to immune diseases. |
| M49354 | Auremolimab | Auremolimab is an ultra-humanized monoclonal antibody against IL-2Rβ (CD122) that targets and depletes tissue-resident memory T-cells, and may be used in vitiligo-related studies. |
| M45367 | Genakumab | Genakumab is a monoclonal antibody targeting IL-1β that can be used in studies related to gout. |
| M45223 | Casdozokitug | Casdozokitug is an IgG1κ antibody targeting IL27. |
| M41997 | IL-1β-IN-1 | IL-1β-IN-1, cannabidiol derivative, is a potent IL-1β inhibitor. |
| M41996 | Lys-D-Pro-Thr | Lys-D-Pro-Thr, an IL-1beta analogue, is a potent IL-1 inhibitor. |
| M41995 | IL-1β-IN-2 | IL-1β-IN-2, cannabigerol derivative, is a potent IL-1β inhibitor. |
| M41994 | Y13g dihydrochloride | Y13g dihydrochloride is the potent inhibitor of both AChE and IL-6. |
| M41993 | Truncated ADR58 | Truncated ADR58 is obtained by truncating full-length ADR58 from 71 bases to 31 bases. |
| M41992 | Ro26-4550 | Ro26-4550 is a low micromolar antagonist of IL-2/IL-2Rα binding with an IC50 value of 3 μM. |
| M41990 | Semapimod | Semapimod, an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. |
| M41989 | Hedycoronen A | Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC50s of 9.1 μM, 5.6 μM, and 46.0 μM. |
| M40708 | DC-806 | DC-806 is an orally active small molecule inhibitor of IL-17 for studies related to psoriasis. |
| M40707 | Icotrokinra | Icotrokinra (JNJ-77242113, JNJ-2113) is a novel, orally active IL-23R peptide antagonist for studies related to plaque psoriasis. Icotrokinra exhibits high affinity with human IL-23 receptor hIL-23R with a Kd of 7.1 pM. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in PMBCs (IC50=5.6 pM), and inhibits L-23-induced generation of IFNγ and IL-17A in picomolar levels. |
| M40611 | PF-04236921 | PF-04236921 is a fully human IgG2 monoclonal antibody targeting the interleukin IL-6 for studies related to Crohn's disease and rheumatoid arthritis. |
| M40610 | PF-07275315 | PF-07275315是一种靶向IL-13R，IL-4R和TSLP的三特异性抗体，可用于特应性鼻炎的相关研究。 |
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