| Cat.No. | Name | Information |
|---|---|---|
| M50199 | BAY-3283142 | BAY-3283142 is a soluble guanylate cyclase complex (sGC) stimulator for studies related to hypertension and chronic kidney disease. |
| M31364 | Dolcanatide | Dolcanatide is an orally active uridine analog that is also a guanylate cyclase C (GC-C) agonist with anti-inflammatory activity and may be used in studies related to inflammatory bowel disease. |
| M30877 | LY83583 | LY83583 is a cell-permeable and competitive inhibitor of soluble guanylate cyclase (sGC) with an IC50 value of 2 µM. |
| M29701 | Ataciguat | Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects. |
| M29395 | Mosliciguat | Mosliciguat is a guanylate cyclase activator. |
| M28949 | (Rac)-MGV354 | (Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively. |
| M28724 | Olinciguat | Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay. |
| M27664 | BAY 60-2770 | BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect. |
| M21391 | Praliciguat | Praliciguat (IW-1973) is a potent, orally available promoter of soluble guanylate cyclase, which enhances the NO signaling pathway and is a vasodilator. In HEK-293 cells, Praliciguat (IW-1973) was able to stimulate sGC with an EC50 value of 197 nM. |
| M6491 | BAY 58-2667 hydrochloride | BAY 58-2667 hydrochloride is a potent soluble guanylyl cyclase (sGC) activator. |
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