Alkylator/Crosslinker
| Cat.No. | Name | Information |
|---|---|---|
| M11369 | N-Nitroso-N-methylurea | N-Nitroso-N-methylurea (NMU; MNU; NMH is an effective carcinogenic, mutagenic and teratogenic agent. N-nitroso-n-methylurea is a direct-acting alkylating agent that interacts with DNA. N-nitroso-n-methylurea targets a variety of animal organs to cause various cancers and/or degenerative diseases. N-nitroso-n-methylurea is also a precursor in diazomethane synthesis. |
| M40729 | Diaziquone | Diaziquone is a water-soluble synthetic aziridinyl benzoquinone that selectively alkylates and cross-links DNA, inhibits DNA replication, induces apoptosis, and inhibits the proliferation of tumor cells, with potential antitumor activity. |
| M30947 | Mipicoledine | Mipicoledine is a potential neuro-alkylating agent for study of glioblastoma and metastatic cancers involving the central nervous system. |
| M30458 | Procarbazine | Procarbazine is an orally active alkylating agent, with anticancer activity. Procarbazine can be used in Hodgkin's disease research. |
| M30384 | PIP-199 | PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics. |
| M29899 | KCC-07 | KCC-07 is a potent, selective and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. KCC-07 prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. Anticancer activity. |
| M29513 | SJG-136 | SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity. |
| M28642 | SG3199 | SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249). |
| M28628 | (-)-Irofulven | (-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity. |
| M28129 | Satraplatin | Satraplatin is an alkylating agent, with potent antitumor effect. |
| M10854 | Melflufen hydrochloride | Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide precursor of Melphalan, is an alkylated agent. Melflufen hydrochloride has antitumor activity against multiple myeloma cells and inhibits angiogenesis. Melflufen hydrochloride has irreversible damage to myeloma cell DNA and cytotoxic effects. |
| M10853 | Melflufen | Melflufen (Melphalan flufenamide), a dipeptide precursor of Melphalan, is an alkylator. Melflufen has antitumor activity against multiple myeloma cells and inhibits angiogenesis. Melflufen acts on irreversible damage and cytotoxicity of myeloma cell DNA. |
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