| Cat.No. | Name | Information |
|---|---|---|
| M29773 | 8RK59 | 8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 using copper(I)-mediated click chemistry, resulting in compound 8RK59. |
| M29772 | 8RK64 | 8RK64 is a covalent UCHL1 inhibitor (IC50: 0.32 μM). |
| M29497 | IU1-248 | IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM. |
| M29062 | (R)-FT671 | (R)-FT671 is the R-isomer of FT671. FT671 is a potent, non-covalent and selective USP7 inhibitor. |
| M28037 | USP7/USP47 inhibitor | USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively. |
| M27876 | LCAHA | LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a. |
| M21262 | FT3967385 | FT3967385 is a novel USP30 inhibitor that recapitulates the genetic deletion of USP30 and triggers mitochondrial ubiquitination of PINK1-PARKIN amplification. |
| M13632 | USP7-IN-1 | USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 77 μM, and can be used for the research of cancer. |
| M13627 | DUB-IN-3 | DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c with an IC50 of 0.56 μM for USP8. |
| M13624 | 6RK73 | 6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM). 6RK73 specifically inhibit UCHL1 activity in breast cancer. |
| M10818 | FT827 | FT827 is a selective and covalent ubiquitin-specific protease 7 (USP7) inhibitor (Ki=4.2 µM). FT827 binds to the USP7 catalytic domain (USP7CD; residues 208-560) with an apparent Kd value of 7.8 µM. |
| M10817 | FT671 | FT671 is a potent, non-covalent, selective USP7 inhibitor,IC50 The value is 52 nM, bound to the USP7 catalytic domain Kd The value is 65 nM. |
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