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Abmole Inhibitor Catalog 2017

Complement System Complement System

Inhibitors

Cat.No.  Name Information
M10317 LNP023 hydrochloride (Iptacopan HCl) Iptacopan (LNP023) hydrochloride is a first-in-class orally bioavailable, highly potent and selective complement factor B inhibitor with an IC50 value of 10 nM.
M10145 Danicopan (ALXN2040) Danicopan (ALXN2040; ACH-4471; ACH-0144471) is a highly potent, orally active Factor D inhibitor.
M10140 TLQP-21 TFA TLQP-21 is a VGF-derived peptide, which protects cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis and increases energy expenditure and prevents early phase diet-induced diabetes.
M10114 PMX 205 Trifluoroacetate PMX 205 Trifluoroacetate is a potent complement antagonist of C5a (C5aR; CD88) receptor.
M9199 Avacopan Avacopan (CCX168) is a potent, selective and orally available complement 5a receptor inhibitor with an IC50 of 0.1 nM.
M8983 Compstatin Compstatinis is a 13-residue cyclic peptide, binds to complement component C3 and inhibits complement activation with IC50 of 12 μM. Compstatin exhibits exclusive specificity for primate C3s and does not bind either to C3s from lower mammalian species or to two structural homologs of C3, human C4 and C5.
M1598 Eculizumab Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5.


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