Certificate of Analysis
| Product Name: | PBIT |
| Catalog Number: | M15089 |
| CAS Number: | 2514-30-9 |
Physical and Chemical Properties
| Formula: | C14H11NOS |
| Molecular Weight: | 241.31 |
| Solubility: | DMSO ≥ 40 mg/mL |
| Storage: | 2-8°C |
| Chemical Structure: |  |
Analytical Data
| HPLC: | Shows Min 100.0% purity |
| H-NMR: | Consistent with structure |
Product Information
| Description: | PBIT is a JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor with IC50 values of 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively. It can increase trimethylation of H3K4 in HeLa cells and block the proliferation of tumor cells expressing high levels of JARID1B. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |