Certificate of Analysis


Product Name: PBIT
Catalog Number: M15089
CAS Number: 2514-30-9

Physical and Chemical Properties
Formula: C14H11NOS
Molecular Weight: 241.31
Solubility: DMSO ≥ 40 mg/mL
Storage: 2-8°C
Chemical Structure: PBIT  Structure
Analytical Data
QC Standard: 100.0%
H-NMR: Consistent with structure
Product Information
Description: PBIT is a JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor with IC50 values of 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively. It can increase trimethylation of H3K4 in HeLa cells and block the proliferation of tumor cells expressing high levels of JARID1B.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.