Certificate of Analysis

 

Product Name: GDC046
Catalog Number: M20767
CAS Number: 1258292-64-6

Physical and Chemical Properties
Formula: C16H13Cl2N3O2
Molecular Weight: 350.2
Solubility: DMSO 70 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: GDC046 Structure
Analytical Data
QC Standard: >99%
H-NMR: Consistent with structure
Product Information
Description: GDC046 (Compound 3) is a potent, selective, and orally bioavailable inhibitor of TYK2 with Ki of 4.8 nM, 83.8 nM, 27.6 nM and 253 nM for TYK2, JAK1, JAK2, and JAK3, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.