Certificate of Analysis
| Product Name: | CRBN-6-5-5-VHL |
| Catalog Number: | M29538 |
| CAS Number: | 2362575-45-7 |
Physical and Chemical Properties
| Formula: | C51H69N7O10S |
| Molecular Weight: | 972.2 |
| Form: | Solid |
| Solubility: | DMSO 113.33 mg/mL (ultrasonic) |
| Storage: | -20°C, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | CRBN-6-5-5-VHL is a potent and selective von Hippel-Lindau-based cereblon (CRBN) degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |