Certificate of Analysis

 

Product Name: c-di-AMP disodium
Catalog Number: M58676
CAS Number: 2734909-87-4

Physical and Chemical Properties
Formula: C20H22N10Na2O12P2
Molecular Weight: 702.38
Solubility: DMSO 120 mg/mL; Water 50 mg/mL
Storage: Store at ≤ -20°C, protect from light, sealed
Chemical Structure: c-di-AMP disodium Structure
Analytical Data
QC Standard: ≥99.0%
H-NMR: Consistent with structure
Product Information
Description: c-di-AMP disodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP disodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.