Certificate of Analysis

 

Catalog Number: M7536
Product Name: BMS-935177
CAS Number: 1231889-53-4

Physical and Chemical Properties
Formula: C31H26N4O3
Molecular Weight: 502.56
Solubility: 100 mg/mL in DMSO
Storage: at -20°C
Chemical Structure: BMS-935177 Structure
Analytical Data
HPLC: Shows Min >98% purity
H-NMR: Consistent with structure
Product Information
Description: BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.