Certificate of Analysis
| Product Name: | 6-Mercaptopurine (6-MP) Monohydrate |
| Catalog Number: | M5375 |
| CAS Number: | 6112-76-1 |
Physical and Chemical Properties
| Formula: | C5H6N4OS |
| Molecular Weight: | 170.19 |
| Solubility: | 100 mg/mL in DMSO |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: | -Monohydrate.gif) |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Mercaptopurine inhibits purine nucleotide synthesis and metabolism by inhibiting phosphoribose pyrophosphate amide transferase (PRPP amide transferase). PRPP amide transferase is a rate-limiting enzyme formed by purine. It alters the synthesis and function of RNA and DNA. Mercaptopurine also interferes with nucleoside tautomies and glycoprotein synthesis. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |