Certificate of Analysis

 

Catalog Number: M6253
Product Name: Savolitinib
CAS Number: 1313725-88-0

Physical and Chemical Properties
Formula: C17H15N9
Molecular Weight: 345.36
Solubility: 16 mg/mL in DMSO
Long-term Storage: at -20°C
Chemical Structure: Savolitinib Structure
Analytical Data
HPLC: Shows Min >98% purity
H-NMR: Consistent with structure
Product Information
Description: Savolitinib (volitinib, AZD6094, HMPL-504) is a novel, potent, and selective MET inhibitor currently in clinical development in various indications, including PRCC. The IC50 values of this compound for c-Met and p-Met are 5 nM and 3 nM, respectively. It shows exquisite selectivity for c-Met over 274 kinase.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.