Certificate of Analysis


Catalog Number: M5005
Product Name: Regorafenib Monohydrate
CAS Number: 1019206-88-2

Physical and Chemical Properties
Formula: C21H17ClF4N4O4
Molecular Weight: 500.83
Solubility: 10 mM in ethanol
Long-term Storage: at -20°C
Chemical Structure: Regorafenib Monohydrate Structure
Analytical Data
HPLC: Shows Min >98% purity
H-NMR: Consistent with structure
Product Information
Description: Regorafenib is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM, respectively.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.