Certificate of Analysis

 

Product Name: PD 0332991 HCL
Catalog Number: M1806
CAS Number: 827022-32-2

Physical and Chemical Properties
Formula: C24H29N7O2.HCl
Molecular Weight: 483.99
Solubility: DMSO 4 mg/mL warmed; Water 30 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: PD 0332991 HCL Structure
Analytical Data
QC Standard: 99.90%
H-NMR: Consistent with structure
Product Information
Description: PD-0332991 HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.