Certificate of Analysis

 

Catalog Number: M5267
Product Name: E7449
CAS Number: 1140964-99-3

Physical and Chemical Properties
Formula: C18H15N5O
Molecular Weight: 317.34
Solubility: 4 mg/mL in DMSO
Long-term Storage: at -20℃
Chemical Structure: E7449 Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: E7449 is an orally bioavailable, brain penetrable, small molecule dual inhibitor of PARP1/2 that also inhibits PARP5a/5b, otherwise known as tankyrase1 and 2 (TNKS1/2), important regulators of canonical Wnt/β-catenin signaling. It has IC50 values of 1.0 and 1.2 nM for PARP1 and 2, respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.