Certificate of Analysis

 

Catalog Number: M5307
Product Name: Afatinib dimaleate
CAS Number: 850140-73-7

Physical and Chemical Properties
Formula: C24H25ClFN5O3.2C4H4O4
Molecular Weight: 717.18
Solubility: 100 mg/mL in DMSO
Long-term Storage: at -20℃
Chemical Structure: Afatinib dimaleate Structure
Analytical Data
HPLC: Shows Min >99% purity
H-NMR: Consistent with structure
Product Information
Description: Afatinib (BIBW2992) Dimaleate irreversibly inhibits EGFR/HER2 including EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively; 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month.