Certificate of Analysis
| Product Name: | ZAK-IN-1 |
| Catalog Number: | M66381 |
| CAS Number: | 2362525-64-0 |
Physical and Chemical Properties
| Formula: | C27H19F2N7O3S |
| Molecular Weight: | 559.55 |
| Solubility: | DMSO 90 mg/mL |
| Storage: | 4°C, sealed |
| Chemical Structure: |  |
Product Information
| Description: | ZAK-IN-1 is an orally active and selective selective leucine-zipper and sterile‑α motif kinase (ZAK) inhibitor with IC50 of 4 nM and KD of 8 nM. ZAK-IN-1 exhibits excellent selectivity against a panel of 403 wild-type kinases. ZAK-IN-1 blocks p38/GATA-4 and JNK/c-Jun signaling and shows promising anti antihypertrophic cardiomyopathy (HCM) efficacy. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |