Product Name: | YF-452 |
Catalog Number: | M29047 |
CAS Number: | 1951466-83-3 |
Formula: | C24H26BrN3O |
Molecular Weight: | 452.39 |
Storage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
Chemical Structure: |
QC Standard: | ≥99.0% |
H-NMR: | Consistent with structure |
Description: | YF-452 is a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2). YF-452 remarkably inhibits the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity. YF-452 inhibits VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. YF-452 is a potential antiangiogenic agent candidate for cancer research. |
Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |