Product Name: | Y-27632 dihydrochloride |
Catalog Number: | M1817 |
CAS Number: | 129830-38-2 |
Formula: | C14H21N3O.2HCl |
Molecular Weight: | 320.26 |
Solubility: | Water ≥ 60 mg/mL; DMSO ≥ 35 mg/mL |
Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Chemical Structure: |
QC Standard: | 99.98% |
H-NMR: | Consistent with structure |
Description: | Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. In addition, Y-27632 inhibited LPA-induced entosis. |
Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |