Certificate of Analysis


Product Name: Y-27632 dihydrochloride
Catalog Number: M1817
CAS Number: 129830-38-2

Physical and Chemical Properties
Formula: C14H21N3O.2HCl
Molecular Weight: 320.26
Solubility: Water ≥ 60 mg/mL; DMSO ≥ 45 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Y-27632 dihydrochloride Structure
Analytical Data
QC Standard: 99.72%
H-NMR: Consistent with structure
Product Information
Description: Y-27632 is a potent, selective inhibitor of Rho-associated protein kinases (ROCK) with IC50 values of 140-220 nM for ROCK1 and ROCK2. In addition, Y-27632 inhibited LPA-induced entosis.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.