Certificate of Analysis
| Product Name: | Varenicline hydrochloride |
| Catalog Number: | M9058 |
| CAS Number: | 230615-23-3 |
Physical and Chemical Properties
| Formula: | C13H14ClN3 |
| Molecular Weight: | 247.72 |
| Form: | Solid |
| Solubility: | DMSO: ≥ 2 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >98.5% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Varenicline hydrochloride is a potent partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR, with EC50s of 2.3 μM and 55 μM, respectively. In addition, Varenicline hydrochloride is also a potent full agonist of α7 nAChRs. In addition, Varenicline hydrochloride is a potent full α7 nAChRs agonist with an EC50 of 18 μM. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |