Certificate of Analysis
| Product Name: | Umbralisib tosylate |
| Catalog Number: | M45298 |
| CAS Number: | 1532533-72-4 |
Physical and Chemical Properties
| Formula: | C38H32F3N5O6S |
| Molecular Weight: | 743.75 |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Umbralisib tosylate is an orally potent, selective dual inhibitor of PI3Kδ and casein kinase-1-ε (CK1ε) with EC50s of 22.2 nM and 6.0 μM, respectively.Additionally, Umbralisib tosylate has demonstrated unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib tosylate Umbralisib tosylate can be used in the study of hematologic malignancies. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |