Certificate of Analysis

 

Product Name: Tucidinostat (Chidamide) HCl
Catalog Number: M10534
CAS Number: 743420-02-2

Physical and Chemical Properties
Formula: C22H21Cl2FN4O2
Molecular Weight: 463.33
Solubility: DMSO ≥ 60 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Tucidinostat (Chidamide) HCl Structure
Analytical Data
QC Standard: >98.5%
H-NMR: Consistent with structure
Product Information
Description: Tucidinostat (HBI-8000; Chidamide; CS-055) HCl is a benzamide type inhibitor of histone deacetylase (HDAC) isoenzymes 1, 2, 3 and 10 with IC50 values of 95, 160, 67, 78 nM for HDAC1, 2, 3, 10 respectively.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.