Certificate of Analysis
| Product Name: | Tofersen |
| Catalog Number: | M21583 |
| CAS Number: | 2088232-70-4 |
Physical and Chemical Properties
| Molecular Weight: | 7128.00 |
| Solubility: | Water ≥ 60 mg/mL |
| Storage: | -20°C, dry, sealed |
Analytical Data
| QC Standard: | ＞96% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce SOD1 protein synthesis. Tofersen can be used in amyotrophic lateral sclerosis (ALS) research. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |