Certificate of Analysis
| Product Name: | Sorafenib Tosylate |
| Catalog Number: | M1827 |
| CAS Number: | 475207-59-1 |
Physical and Chemical Properties
| Formula: | C21H16ClF3N4O3.C7H8O3S |
| Molecular Weight: | 637.03 |
| Solubility: | DMSO 30 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 100.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Sorafenib (BAY 43-9006) Tosylate is an orally active multikinase inhibitor of tyrosine protein kinases VEGFR/PDGFR and RAF/MEK/ERK with IC50 values of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |