Certificate of Analysis
| Product Name: | SJFα |
| Catalog Number: | M29458 |
| CAS Number: | 2254609-27-1 |
Physical and Chemical Properties
| Formula: | C59H67F2N7O11S |
| Molecular Weight: | 1120.27 |
| Form: | Solid |
| Solubility: | DMSO 100 mg/mL (ultrasonic and warming and heat to 60°C) |
| Storage: | Powder -20°C |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | SJFα is a 13-atom linker PROTAC based on von Hippel-Lindau ligand. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |