Certificate of Analysis


Product Name: SIS3 HCl
Catalog Number: M8149
CAS Number: 521984-48-5

Physical and Chemical Properties
Formula: C28H27N3O3.HCl
Molecular Weight: 489.99
Solubility: DMSO: ≥ 70 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: SIS3 HCl Structure
Analytical Data
QC Standard: 99.53%
H-NMR: Consistent with structure
Product Information
Description: SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3 with an IC50 of 3 µM.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.