Certificate of Analysis


Catalog Number: M2277
Product Name: Semagacestat
CAS Number: 425386-60-3

Physical and Chemical Properties
Formula: C19H27N3O4
Molecular Weight: 361.44
Solubility: DMSO 62 mg/mL
Storage: at -20°C
Chemical Structure: Semagacestat Structure
Analytical Data
HPLC: Shows Min 97.69% purity
H-NMR: Consistent with structure
Product Information
Description: Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.