Certificate of Analysis


Product Name: S-Ruxolitinib
Catalog Number: M3030
CAS Number: 941685-37-6

Physical and Chemical Properties
Formula: C17H18N6
Molecular Weight: 306.37
Solubility: DMSO 51 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: S-Ruxolitinib  Structure
Analytical Data
QC Standard: 100.00%
H-NMR: Consistent with structure
Product Information
Description: S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.