| Description: |
(S,R)-GSK321 is a potent and selective inhibitor of mutant IDH1, inhibiting R132G, R132C, R132H, and WT IDH1 with IC50 values of 2.9, 3.8, 4.6, and 46 nM, respectively, with a 100-fold higher selectivity than IDH2. (S,R)-GSK321 induces a reduction in intracellular 2-HG, failure of myeloid differentiation blockade, and induction of granulocyte differentiation at the level of leukemoblasts and more immature stem cells. (S,R)-GSK321 can be used in studies related to acute myeloid leukemia (AML) and other cancers. |
| Stability and Solubility Advice: |
Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |
