Certificate of Analysis
| Product Name: | Ro 25-6981 maleate salt |
| Catalog Number: | M8367 |
| CAS Number: | 1312991-76-6 |
Physical and Chemical Properties
| Formula: | C22H29NO2.C4H4O4 |
| Molecular Weight: | 455.54 |
| Form: | Solid |
| Solubility: | DMSO 60 mg/mL; Water 4 mg/mL (warmed) |
| Storage: | 4°C, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 98.13% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Ro 25-6981 maleate salt is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit with IC50 values of .009 μM for NR2B vs. 52 μM for NR2A subunits. Ro 25-6981 has been shown to have neuroprotectant effects and to reduce inflammatory and neuropathic pain in rodent models. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |