Product Name: | PU02 |
Catalog Number: | M25487 |
CAS Number: | 313984-77-9 |
Formula: | C16H12N4S |
Molecular Weight: | 292.36 |
Solubility: | DMSO >100 mg/mL |
Storage: | -20°C, sealed |
Chemical Structure: |
QC Standard: | >99.0% |
H-NMR: | Consistent with structure |
Description: | PU02 (NMMP) is a potent and selective negative allosteric modulator (NAM) of 5-HT3 receptor, displaying IC50 values of ~1 μM at 5-HT(3)Rs and substantially lower activities at other Cys-loop receptors. PU02 inhibits the proliferation of hepatocellular carcinoma (HepG2) cells associated with G2/M phase cell cycle arrest, and reduced cyclin-dependent kinase (CDK) 4 and cyclin B1/D1 levels. |
Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |