Certificate of Analysis

 
Product Name: PROTAC Sirt2 Degrader-1 
Catalog Number: M29225
CAS Number: 2098487-75-1
Physical and Chemical Properties
Formula: C40H40N10O8S2
Molecular Weight: 852.94
Form: Solid
Solubility: DMSO ≥ 100 mg/mL
Storage: Powder -20°C
Chemical Structure: PROTAC Sirt2 Degrader-1  Structure
Analytical Data
QC Standard: ≥99.0%
H-NMR: Consistent with structure
Product Information
Description: PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM).
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.