Certificate of Analysis
| Product Name: | PROTAC PD-1/PD-L1 degrader-1 |
| Catalog Number: | M29649 |
| CAS Number: | 2447066-37-5 |
Physical and Chemical Properties
| Formula: | C59H58ClN7O11 |
| Molecular Weight: | 1076.59 |
| Form: | Solid |
| Solubility: | DMSO 210 mg/mL (ultrasonic) |
| Storage: | -20°C, protect from light, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |